Factor Xa
Fxa
Factor Xa, a trypsin-like serine protease, is situated at the critical juncture between the intrinsic and extrinsic pathways, catalyzing the conversion of prothrombin to thrombin, and hence plays a pivotal role in the final common pathway of the cascade and has become an important target in the discovery and development of new anticoagulants. Factor Xa is a key protease of the coagulation pathway whose activity is known to be in part modulated by binding to factor Va and sodium ions.
Blood coagulation involves a complex cascade of enzymatic reactions, ultimately generating fibrin, the basis of all blood clots. This cascade is comprised of two arms, the intrinsic and extrinsic pathways which converge at factor Xa to form the common pathway. Factor Xa activates prothrombin to thrombin, which in turn catalyzes the conversion of fibrinogen to fibrin.
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Factor Xa Related Products (167)
Related Products (167)
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Antibodies (1)
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Lyso-sulfatide (bovine)
0 ImagesCat. No.: HY-166257CAS No.: 38621-58-8Synonyms: Psychosine 3′-O-sulfate; Psychosine 3′-sulfateLyso-sulfatide (bovine) is a phospholipid component derived from sphingolipid catabolism and a potent factor Xa inhibitor and anticoagulant. Lyso-sulfatide (bovine) binds directly to factor Xa and inhibits prothrombin activation mediated by the prothrombinase complex, thereby prolonging factor Xa-induced plasma clotting time and suppressing thrombin generation. Lyso-sulfatide (bovine) serves as a reliable lipid membrane mimic for studying cell membrane structure, function, and molecular interactions.
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Lofacimig
0 ImagesCat. No.: HY-P991006CAS No.: 2857858-76-3Synonyms: KN-060HY-P991006 is an FXI/PTA-targeting VH-VH-G1(h-CH2-CH3) dimer type bispecific antibody.
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FXa-IN-2
0 ImagesCat. No.: HY-179017CAS No.: 1379458-40-8FXa-IN-2 (Compound K3) is a reversible FXainhibitor, with an IC50 value of 45.08 μM. FXa-IN-2 can be used in the research of thromboembolic diseases.
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5-Chlorothiophene-2-carboxylic acid (Standard)
0 ImagesCat. No.: HY-76835RCAS No.: 24065-33-65-Chlorothiophene-2-carboxylic acid (Standard) is the analytical standard of 5-Chlorothiophene-2-carboxylic acid. This product is intended for research and analytical applications. 5-Chlorothiophene-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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Asundexian-d3
0 ImagesCat. No.: HY-137431SCAS No.: 2975248-62-3Synonyms: BAY-2433334-d3Asundexian-d3 (BAY-2433334-d3) is the deuterium labeled Asundexian (HY-137431). Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM.
